Finally, 32 articles were included in both systematic review and meta-analysis (Figure 1). Among these, 55 full-text articles were included for further assessment of eligibility. After removing duplicates, the titles and abstracts of the remaining 2064 records were screened. Overall, a total of 2612 records were identified from searched electronic databases and additional hand searching. This report complies with The Preferred Reporting Items for Systematic review and Meta-Analysis/ PRISMA guidelines (Supplementary Table 3 for checklist). 2 In the United States, generic drugs are approved through the Abbreviated New Drug Application by the U.S. 1 These drugs are known to have a narrow therapeutic index (NTI), which means small differences in dose or blood concentration can lead to serious therapeutic failures and/or adverse events (AEs). ![]() Calcineurin inhibitors (CNI) such as oral ciclosporin-A (CsA) and tacrolimus (TAC) are indicated for the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants.
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